Company Overview

Cytonics is a biotechnology research and development company that specializes in developing diagnostics and therapeutics for osteoarthritis. Our flagship product was the Fibronectin-Aggrecan Complex Test (“FACT™”), which can detect cartilage damage due to osteoarthritis from samples of patients’ joint fluid. We licensed FACT™ to Synthes (acquired by Johnson & Johnson) in 2011, and it has been used by hundreds of physicians to diagnose and direct patients’ course of treatment.

Discovery of FAC as a biomarker for osteoarthritis led to the identification of a naturally-occurring blood protein, Alpha-2 Macroglobulin (A2M), which protects cartilage from degradation and can alleviate joint pain. We developed an autologous therapy (“APIC™”) based upon the function of A2M, which has sold directly to physicians by a national medical device distributor since 2015. Over 6,000 patients, ranging from the elderly to young athletes, have been treated to date. We are developing new A2M-based therapies with the goal of out-licensing to strategic partners at critical clinical value inflection points. Cytonics’ mission is to rid the world of the pain, suffering, and reduced quality of life caused by osteoarthritis. Supported by hundreds of physicians nationwide, we are a leader in the field of regenerative medicine and are positioned to disrupt the space with our innovative biologic therapies for osteoarthritis.

Our mission is to rid the world of the pain, suffering, and reduced quality of life caused by osteoarthritis.

Our Research

APIC™ SYSTEMOur breakthrough technology is based upon a naturally occurring molecule within the body. This molecule, alpha-2-macroglobulin (A2M), is found within...Learn More
CYT-108We have designed and tested a synthetic (recombinant) version of the naturally occuring A2M molecule. This recombinant therapy improves upon Nature's design and...Learn More
FACT™ Diagnostic
FACT™ DiagnosticWe have developed biomarker assay (Fibronective-Aggrecan Complex Test, FACT™) to identify symptomatic intervertebral discs or painful joint abnormalities. FACT™ is used to...Learn More
Intellectual Property
Intellectual PropertyCytonics has made considerable investments in R&D and has filed numerous domestic and international patent applications for its diagnostic and therapeutic technologies...Learn More


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Our Partnerships

The company has developed relationships with researchers and clinicians at leading institutions around the country including Stanford University, University of Pittsburgh, Thomas Jefferson University, University of Michigan, NYU Hospital For Joint Diseases, and Beaumont Health System. Cytonics also has relationships with local institutions including The Scripps Research Institute, Florida Atlantic University, and Palm Beach State College.  The company has sponsored research at Stanford University to study the use of FACT for patients with radiculopathic back pain, and at the University of Pittsburgh to investigate the effect of APIC™ on preventing spinal disc degeneration.