MARCH 4, 2015
Jupiter, FL: Cytonics Corporation, a biotechnology company focused on the development of biologic therapies for musculoskeletal diseases, today announced that the Intellectual Property Office of the UK granted patent GB2501611B covering both a biological composition of concentrated Alpha-2-Macroglobulin (A2M) and a recombinant variant of the naturally occurring A2M molecule. This proprietary technology is being developed to treat cartilage degeneration in diseases such as osteoarthritis.
Alpha-2-Macroglobulin (A2M) is an abundant, endogenous blood protein that inhibits all classes of serine proteases and metalloproteases, thereby decreasing protein degradation involved in osteoarthritis and attenuating joint pain. Cytonics’ recombinant Alpha-2-Macroglobulin variant, CYT-108, is a synthesized protein that contains a series of mutations within the bait region of the protein structure. The mutated bait region was designed to increase the potency of the A2M molecule, allowing small doses to have large therapeutic effects.
“We are confident that Cytonics’ innovation in the world of regenerative medicine will translate into clinical success. Our autologous A2M therapy (APIC) has already demonstrated outstanding success in practice, which gives us a tremendous amount of confidence that our recombinant A2M variant, CYT-108, will be an effective treatment for osteoarthritis.”Gaetano Scuderi, MD
CEO of Cytonics
Cytonics, founded in 2006, is a private research and development company focusing on molecular diagnostic and therapeutic products for chronic musculoskeletal diseases. The company developed the FACT diagnostic test which helps identify the source of back and joint pain and assists physicians in determining the most appropriate treatment. Cleared in January of 2014, Cytonics developed the Autologous Platelet-Integrated Concentrate (APIC) System as a
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