Understanding A2M and the Role It Plays Against Bad Chemicals

Joint Pain TreatmentChemical Causes of Joint Pain

Understanding the roles of A2M, including inflammatory cytokines, can be useful in understanding your treatment options and how you can expect them to relieve your pain. What can at first appear to be an alphabet soup of unfamiliar terms will be clear as you understand the roles these chemicals play in your joint pain.

Our bodies are a wonder of chemical production and regulation. Over time, however, certain chemicals can get out of balance and produce painful effects. Your body produces cytokines that help the immune system in fighting diseases. However, when certain types of these cytokines are present in sufficient quantities in your joints, inflammation, pain, and destruction of cartilage can result. Many other factors, of course, can produce joint pain as well, but inflammation as a result of these bad chemicals is commonly a factor in producing joint pain.

A2M and Treating Inflammation

A2M is a natural protein produced by your body and present in blood plasma. A2M’s role is to protect tissue (like cartilage) from some of these “bad chemicals” (inhibiting cartilage breakdown for example). Joint pain is often associated with low levels of A2M. A study from Brown university showed that concentrated injections of A2M into the joint can effectively fight cartilage damage and inflammation. A2M destroys the chemicals causing inflammation and joint pain and returns the joint to proper balance. A2M is a relatively large molecule, and there can be several reasons, such as an injury, that may keep A2M from reaching joints effectively. By injecting this powerful protein directly into the joint, A2M can provide joint pain relief and protect cartilage by destroying the chemicals that harm the joint.

How A2M Does Its Job

Produced in the liver, the A2M protein circulates through a healthy blood stream carried in your plasma. When A2M comes across cartilage destroying enzymes, special sites on the protein bind with the enzymes to trap and then carry them away. Once the A2M protein has filled each of its binding sites, the protein is flushed from the body, thus removing the harmful chemicals that destroy your cartilage. When the system is healthy, this takes place naturally without any special intervention. After an injury, however, the system may not function properly, which results in joint pain. Even a minor injury can impede the flow of A2M, causing discomfort and limitation that can be misleading. Additionally, as we age, the process of A2M circulation tends to become less effective. In these cases, a concentrated injection of A2M may restore the joint to proper working order and relieve the inflammation and pain.

At Cytonics we’re dedicated to discovering and developing therapeutics based on the protease inhibitor A2M. Contact us to learn more about our research and treatments.