Cytonics Blog

  1. What Is Alpha-2-Macroglobulin Injection Treatment?

    Osteoarthritis A2M TreatmentAlpha-2-macroglobulin, or A2M, is a cartilage catabolic factor inhibitor with the power to stop the progression of osteoarthritis (OA). It’s found naturally in the blood. Treatments using A2M through Cytonics Corporation may be able to help patients with OA by preventing the breakdown and loss of cartilage. Cytonics uses its own original, breakthrough technology to administer these treatments directly to the joint space in need. Here’s what you need to know about this innovative treatment.

    How Does A2M Work to Stop Osteoarthritis?

    Osteoarthritis is the most common form of arthritis, and one of the most prevalent health problems today. It affects about 27 million Americans. OA is a degenerative disease in which the tissues that cover joints break down and eventually wear away completely. This results in the two bones rubbing painfully together, instead of gliding, as they do when joints are healthy. Thanks to Cytonics’ A2M injection treatment, OA doesn’t have to be forever. Recent scientific studies indicate that Cytonics’ A2M injection treatment may offer lasting protection from joint collapse.

    During our A2M injection treatments, we use the molecular technology we developed to concentrate the A2M in your blood, in order to deliver high amounts to the joint space. A2M is a special inhibitor because it protects the cartilage in your body from the destructive proteins (catabolic proteases) that break down cartilage and cause OA. Treatments using A2M, such as Cytonics’ unique therapy, mimic natural processes to prevent cartilage loss, promote tissue growth, and support the restoration of a healthy joint.

    A2M injections with Cytonics’ special molecular technology results in plenty of A2M available to bind and stop chemicals in joints that are responsible for causing OA. The A2M fills the joint space, captures the catabolic proteases, and neutralizes their harmful degenerative effects – effectively halting osteoarthritis and related pain in their tracks. A2M doesn’t stop there. It then works to promote the regrowth of lost or worn-away cartilage in the joint to repair damage and ultimately restore pain-free use of the joint.

    A2M Injection Treatment Clinical Trials

    Cytonics Corporation is the only company with patented technology for concentrating A2M. Our device uses the patient’s own blood to remove the cells and inject concentrated A2M to the affected joint.

    Our special Autologous Protease Inhibitor Concentrate System has received Food and Drug Administration (FDA) approval to move onto the Investigational New Drug Clinical Trial stage for the treatment of osteoarthritis. The ongoing 2016 study indicates a strong safety profile and reduction of pain after eight weeks – a positive step for the future of alpha-2-macroglobulin injection treatments.


  2. How to Know If A Person Has Osteoarthritis

    How To Know If You Have OsteoarthritisIt’s common to experience some soreness or stiffness in joints or in the back, especially after waking up or after sitting for an extended period. If this is happening more frequently, you may be wondering if these are the early signs of osteoarthritis (OA). If so, you are not alone. The most common cause of joint disorder in the US is osteoarthritis, affecting 10 percent of men and 13 percent of women over 60. This number is poised to grow over the coming years.

    Here are some signs to look for that may indicate osteoarthritis.

    Pain and Tenderness

    Early arthritis pain manifests as an aching pain and tenderness. Moving a joint in a particular way may cause a sharper pain that can indicate this is more than normal soreness. Additionally, you may experience a tenderness revealed by pressing on the joint. If this pain and tenderness continues or returns regularly, this may well be an early sign of osteoarthritis.

    Stiffness of Joints

    Taken alone, it can be hard to discern if the stiffness you feel on waking up or after sitting for a while is a symptom of osteoarthritis or a normal part of life. As the joints warm up, the stiffness is likely to be relieved, further obscuring the fact that this may well be a symptom of a bigger problem. If this stiffness is accompanied by one or more of the other symptoms listed here, it may well be an indicator of osteoarthritis.

    Lost Range of Motion

    Joints have a natural range of motion that allows freedom of movement. As osteoarthritis progresses, you may observe this range of motion becoming increasingly limited. Pay attention if your knee no longer bends as far as it used to, or if you are unable to raise your arm all the way anymore. This usually comes on gradually, but becomes more apparent as the osteoarthritis progresses.

    Symptoms With No Apparent Cause

    Waking up with a sore, stiff back may seem normal. If you find yourself sore and stiff during the day without being able to identify an activity that may have brought the soreness about, this may well be a sign that osteoarthritis is the cause.

    If you observe these symptoms, it is best to consult your doctor about them sooner rather than later. Getting an early diagnosis can help you be proactive in taking measures to combat the progression of the disorder and prolong your quality of life.

    Treatment for OA

    An emerging treatment option for osteoarthritis includes Alpha-2-Macroglobulin (A2M) injections. A2M is a natural protein the body produces that prevents cartilage from breaking down, thus stopping the progression of OA and providing joint pain relief.

    To find a physician in your area who offers A2M treatment, click here or contact Cytonics at

  3. Understanding A2M and the Role It Plays Against Bad Chemicals

    Understanding A2M CytonicsChemical Causes of Joint Pain

    Understanding the roles of A2M, including inflammatory cytokines, can be useful in understanding your treatment options and how you can expect them to relieve your pain. What can at first appear to be an alphabet soup of unfamiliar terms will be clear as you understand the roles these chemicals play in your joint pain.

    Our bodies are a wonder of chemical production and regulation. Over time, however, certain chemicals can get out of balance and produce painful effects. Your body produces cytokines that help the immune system in fighting diseases. However, when certain types of these cytokines are present in sufficient quantities in your joints, inflammation, pain, and destruction of cartilage can result. Many other factors, of course, can produce joint pain as well, but inflammation as a result of these bad chemicals is commonly a factor in producing joint pain.

    A2M and Treating Inflammation

    A2M is a natural protein produced by your body and present in blood plasma. A2M’s role is to protect tissue (like cartilage) from some of these “bad chemicals” (inhibiting cartilage breakdown for example). Joint pain is often associated with low levels of A2M. A study from Brown university showed that concentrated injections of A2M into the joint can effectively fight cartilage damage and inflammation. A2M destroys the chemicals causing inflammation and joint pain and returns the joint to proper balance. A2M is a relatively large molecule, and there can be several reasons, such as an injury, that may keep A2M from reaching joints effectively. By injecting this powerful protein directly into the joint, A2M can provide joint pain relief and protect cartilage by destroying the chemicals that harm the joint.

    How A2M Does Its Job

    Produced in the liver, the A2M protein circulates through a healthy blood stream carried in your plasma. When A2M comes across cartilage destroying enzymes, special sites on the protein bind with the enzymes to trap and then carry them away. Once the A2M protein has filled each of its binding sites, the protein is flushed from the body, thus removing the harmful chemicals that destroy your cartilage. When the system is healthy, this takes place naturally without any special intervention. After an injury, however, the system may not function properly, which results in joint pain. Even a minor injury can impede the flow of A2M, causing discomfort and limitation that can be misleading. Additionally, as we age, the process of A2M circulation tends to become less effective. In these cases, a concentrated injection of A2M may restore the joint to proper working order and relieve the inflammation and pain.

    At Cytonics we’re dedicated to discovering and developing therapeutics based on the protease inhibitor A2M. Contact us to learn more about our research and treatments.